P-selectin, the largest selectin, is stored in α-granules of platelets and in Weibel–Palade bodies of endothelial cells, and is translocated to the cell surface of activated endothelial cells and platelets. E-selectin is not expressed under baseline conditions, except in skin microvessels, but is rapidly induced by inflammatory cytokines.

title = "P-Selectin and P-Selectin Glycoprotein Ligand 1 Mediate Rolling of Activated CD8+ T Cells in Inflamed Colonic Venules.",. abstract = "BACKGROUND::

P-selectin fungerar som en celladhesionsmolekyl P-Selectin, Human, Recombinant, CHO Cells. Produktnummer. : 561306. Märke. : Millipore.

För att minska smittspridning är det besöksförbud (utom för vårdnadshavare). P-Selectin is a calcium-dependent receptor that funtions as a cell adhesion molecule on the surfaces of activated endothelial cells. It binds to carbohydrates on neutrophils and monocytes. It is the primary ligand for the P-Selectin glycoprotein ligand-1 and is important in the initial recruitment of leukocytes and platelets during inflammation and injury. Recombinant Human P-Selectin Protein (Met1-Ala771) 13025-H02H with a fusion hFc Tag, is expressed in HEK293 Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human P-Selectin protein for relevant bioassay and related research. Upon injury in a blood vessel, platelets become activated and adbere to prevent blood loss.

The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from … "P-Selectin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. 2 days ago P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. [5] P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets .

Mastceller; Vasdilation; P-selectin. PGD2, PGE2. Leukocyter; Vasodilation; Kärlpermeabilitet. LTC4, LTD4. Leukocyter; Vasokonstriktion

2 days ago P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. [5] P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets . P-Selectin (CD62P), previously termed PADGEM or GMP-140, is a single chain glycoprotein of 140 kDa expressed in platelets and endothelial cells. In platelets, P-selectin is stored in α granules, whereas in endothelial cells it is found in Weibel–Palade bodies.

partial thromboplastin time. P-selectin receptor exposed during either platelet or endothelial cell release reaction. RIA radioimmunoassay. S-12.

Background: P-Selectin/CD62P. The Selectin family is comprised of three members, E-Selectin, L-Selectin, and P-Selectin. E-Selectin [endothelial leukocyte adhesion molecule-1 (ELAM-1), CD62E] is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha. The R-PLEX platform offers matched sets of antibodies and calibrators for a wide menu of biomarkers.

as well as inhibition of the expression of the adhesion molecule P-selectin on endothelial cells.
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What does p-selectin mean? Information and translations of p-selectin in the most comprehensive dictionary definitions resource on the web. 2021-03-22 · P-selectin is expressed in trauma-induced coagulopathy with mechanical dysfunction.

P-selectin glycoprotein ligand 1 and beta Kinetics of platelet P-selectin mobilization: Concurrent surface expression and release induced by thrombin or PMA, and inhibition by the NO Donor SNAP av S Santén · 2009 · Citerat av 14 — Additionally, the role of p38 MAPK in mast cell-generated tumor necrosis factor-α (TNF-α) as well as neutrophil adhesion and P-selectin expression were Artikelnummer: 636393. Produktnamn: Ms X Hu P Selectin. REACH- registreringsnummer: Denna produkt är en blandning.
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P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets.

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P-selectin belongs to the family of selectin adhesion molecules, and is expressed by platelets and endothelial cells on stimulation. This pattern of expression

Summary: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. Identifying severe acute pancreatitis (SAP) as soon as possible is critical for achieving optimal outcomes and saving lives. In this study, a novel P-selectin-targeted, NIR fluorescent dye (Cy 5.5)-labeled dual-modal nanoprobe based on diethylenetriaminepentaacetic chelates (Gd-DTPA-Cy5.5-PsLmAb) was constructed for the bimodal imaging of SAP at the early stage. Gd-DTPA-Cy5.5-PsLmAb was 2003-12-01 Mechanisms for increasing synthesis of P-selectin are suggested by its presence on the apical surface of endothelial cells in human tissues with chronic or allergic inflammation.16-18 Indeed, TNF-α, IL-1β, or LPS increases expression of P-selectin mRNA and protein in murine endothelial cells in vitro and in vivo.10,19,20 Transient activation of the murine P-selectin gene requires the P-selectin is a 140-kDa transmembrane glycoprotein. Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis. Materials and Methods.

1993-04-01 · Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

It binds to carbohydrates on neutrophils and monocytes. It is the primary ligand for the P-Selectin glycoprotein ligand-1 and is important in the initial recruitment of leukocytes and platelets during inflammation and injury. P-selectin deficiency decreases tissue stiffness in Rip1-Tag2 mouse insulinomas. We previously reported that P-selectin deletion significantly inhibits insulinoma growth in Rip1-Tag2 mice [] and that tumor tissue stiffness increases in conjunction with insulinoma progression (Figure 1).To investigate the effects of P-selectin on insulinoma tissue stiffness, we subjected Rip1-Tag2 and Rip1-Tag2 2020-03-01 In this video we discuss the three different types of selectins and their involvement in the immune system. P-selectin plasma from blood samples taken from the subjects of the study was analyzed and compared.

In platelets, P-selectin is stored in α granules, whereas in endothelial cells it is found in Weibel–Palade bodies.